SETD1B Rabbit Polyclonal Antibody

SKU TA347285

Rabbit Polyclonal Setd1b Antibody

Product Data

• Application: ELISA, WB
• Recommended Dilution: ELISA (1:100 ?? 1:500) ; Western blotting (1:500)
• Reactivity: Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Setd1b antibody: mouse Setd1b (Set domain containing 1B), using a 3 KLH-conjugated synthetic peptides containing sequences from the central part of the protein.
• Concentration: lot specific
• Purification: Whole antiserum from rabbit containing 0.05% azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: SET domain containing 1B
• Database Link:
  NP_055863
  Q9UPS6
• Background: SETD1B (UniProt/Swiss-Prot entry Q9UPS6) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1B shows a non-overlapping localization with SETD1A, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression.
• Synonyms: KMT2G; Set1B

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation