KDM1A Rabbit Polyclonal Antibody

SKU TA347222

Rabbit Polyclonal LSD1 Antibody

Product Data

• Application: ELISA, IF, WB
• Recommended Dilution: ChIP/ChIP-seq (2-5ug/ChIP); ELISA (1:200 ?? 1:1,000); Western blotting (1:1,000); IF (1:500)
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-LSD1 antibody: human LSD1 (Lysine-specific demethylase 1), using a KLH-conjugated synthetic peptide from the inner part of the protein.
• Concentration: lot specific
• Purification: Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: lysine demethylase 1A
• Database Link:
  NP_001009999
  O60341
• Background: LSD1 (lysine specific demethylase 1, UniProt/Swiss-Prot entry O60341) is a component of the histone demethylase complex that uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono- and dimethylated 'Lys-4' of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. LSD1 therefore mediates different processes such as embryonic development, cell differentiation and proliferation, stem and cancer cell biology.
• Synonyms: AOF2; BHC110; CPRF; KDM1; LSD1

Reference Data

• Protein Families: Druggable Genome, Transcription Factors