H3FA (HIST1H3A) Rabbit Polyclonal Antibody

CAT#: TA347192

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Rabbit Polyclonal H3K27me3 Antibody


Product Datasheet for 'TA347192'


USD 430.00


Availability*
5 Days

Size
    • 50 ug


Specifications

Product Data
Applications Assay, Dot, ELISA, IF, WB
Recommended Dilution ChIP/ChIP-seq (1ug/ChIP); ELISA (1:200); Dot blotting (1:5,000); Western blotting (1:500); Immunofluoresence (1:200)
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-H3K27me3 antibody: against histone H3, trimethylated at lysine 27 (H3K27me3), using a KLH-conjugated synthetic peptide.
Concentration 1.45 µg/µl
Purification Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Gene Name histone cluster 1, H3a
Background Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Trimethylation of histone H3K27 is associated with gene repression.
Synonyms H3/A; H3FA
Reference Data
Protein Pathways Systemic lupus erythematosus
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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