MCM10 Rabbit Polyclonal Antibody

CAT#: TA341690

Rabbit Polyclonal Anti-MCM10 Antibody

Product Images

WB Suggested Anti-MCM10 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate MCM10 is supported by BioGPS gene expression data to be expressed in Jurkat

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-MCM10 antibody: synthetic peptide directed towards the middle region of human MCM10. Synthetic peptide located within the following region: PKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERV
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 98 kDa
• Gene Name: minichromosome maintenance 10 replication initiation factor
• Database Link:
  NP_060988
  Entrez Gene 55388 Human
  UniProt ID Q7L590
• Background: The protein encoded byThis gene is one ofThe highly conserved mini-chromosome maintenance proteins (MCM) that are involved inThe initiation of eukaryotic genome replication.The hexameric protein complex formed by MCM proteins is a key component ofThe pre-replication complex (pre-RC) and it may be involved inThe formation of replication forks and inThe recruitment of other DNA replication related proteins.This protein can interact with MCM2 and MCM6, as well as withThe origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest thatThe chromatin binding ofThis protein atThe onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
• Synonyms: CNA43; DNA43; PRO2249
• Note: Immunogen Sequence Homology: Human: 100%; Horse: 93%; Dog: 86%; Rabbit: 86%; Pig: 77%; Bovine: 77%

Reference Data

• Protein Families: Stem cell - Pluripotency