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CYP1B1 Rabbit Polyclonal Antibody

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SKU
TA339934
Rabbit Polyclonal Anti-CYP1B1 Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $585.00
2 Weeks*
Bulk/Customize

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View other "CYP1B1 or NM_000104" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for Anti-Cyp1b1 antibody is: synthetic peptide directed towards the middle region of human CYP1B1
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 61 kDa
Gene Name cytochrome P450 family 1 subfamily B member 1
Database Link
Background CYP1B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1B1 localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Synonyms CP1B; CYPIB1; GLC3A; P4501B1
Note Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Guinea pig: 100%; Horse: 93%
Reference Data
Protein Categories Growth Factors, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, P450
Protein Pathways Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism
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Documents
Resources

file-alt Citations

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)
Cirillo, Lappano, Bruno et al
J. Exp. Clin. Cancer Res. (2019) 38 (1), 335 DOI: 10.1186/s13046-019-1337-2
AI Summary: OriGene products, specifically the antibodies against CYP1B1 (TA339934) and cyclin D1 (TA801655), were used for western blotting analyses to assess protein expression levels in the study investigating the roles of AHR and GPER in breast cancer cell and fibroblast responses to 3-methylcholanthrene.
Snippet: ferred to a nitrocellulose membrane (Amersham Biosciences, Sigma-Aldrich, Milan, Italy), probed overnight at 4 °C with antibodies against CYP1B1 (TA339934) and cyclin D1 (TA801655) (purchased from OriGene Technologies, DBA, Milan, Italy), GPER (AB137479) (Abcam, Euroclone, Milan, Italy), AHR (D5S6H) (Cell Signalling technology, Euroclone, Milan, Italy), c-Fos (E8), pEGFR Tyr 1173 (sc-12,351), E
FigureFigureFigure
WB IP
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer
Cirillo, Pellegrino, Malivindi et al
Oncotarget (2017) 8 (63), 106608-106624 DOI: 10.18632/oncotarget.22541
Snippet: gel, transferred to a nitrocellulose membrane (Amersham Biosciences, Sigma-Adrich, Milan, Italy), probed overnight at 4°C with antibodies against CYP1B1 (TA339934), cyclin D1 (TA801655), cyclin E (TA590076), cyclin A (TA890057) (OriGene Technologies, DBA;probed overnight at 4°C with antibodies against CYP1B1 (TA339934), cyclin D1 (TA801655), cyclin E (TA590076), cyclin A (TA890057) (OriGene Technologies, DBA, Milan, Italy), c-Fos (E8), GPER (N-15) and β-actin (C-2) (Santa Cruz Biotechnology, DBA)
FigureFigureFigure
Showing 1-2 of 2 papers.
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