GPR183 Rabbit Polyclonal Antibody

SKU TA337161

Rabbit Polyclonal EBI2/GPR183 Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin: 5ug/ml, Western Blot: 2-4ug/ml~
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 300-350 of human EBI2 was used as the immunogen.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at -20C. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: G protein-coupled receptor 183
• Database Link:
  NP_004942
  P32249
• Background: G-protein coupled receptor 183 (EBI2) belongs to the G-protein coupled receptor 1 family of proteins. It is an orphan seven-transmembrane receptor originally identified as most up-regulated gene (>200-fold) in EBV-infected cells. It plays a central role during humoral immunity. It promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. It is expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. It is also reported to be highly expressed in lung, heart and gastrointestinal tract. EBI2 deficiency in mice led to a reduction in the early antibody response to a T-dependent antigen.
• Synonyms: EBI2; hEBI2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane