HEY1 Rabbit Polyclonal Antibody

CAT#: TA337140

Rabbit Polyclonal HEY1 Antibody

Product Images

Western Blot: HEY1 Antibody TA337140 - Analysis of Hey1 in mouse embryo brain lysate using 1) preimmune sera at 1:5000 dilution and 2) purified TA337140. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 2-4ug/ml
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A portion of amino acids 50-100 of mouse Hey1 was used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hes related family bHLH transcription factor with YRPW motif 1
• Database Link:
  NP_001035798
  Entrez Gene 15213 Mouse
  UniProt ID Q9Y5J3
• Background: Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
• Synonyms: BHLHb31; CHF2; HERP2; HESR1; hHRT1; HRT-1; OAF1
• Note: This antibody has been tested in Western blot on mouse tissue. The Western blot results on human tissue have been mixed.

Reference Data

• Protein Families: Druggable Genome, Transcription Factors