Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
Synonyms
BHLHb31; CHF2; HERP2; HESR1; hHRT1; HRT-1; OAF1
Note
This antibody has been tested in Western blot on mouse tissue. The Western blot results on human tissue have been mixed.
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