TLR7 Rabbit Polyclonal Antibody

SKU TA336419

Rabbit Polyclonal TLR7 Antibody

Product Data

• Application: FC, IHC
• Recommended Dilution: Flow Cytometry, Flow (Intracellular): 0.5 - 2 ug/1x10^6 cells, Immunohistochemistry: 1:10 - 1:500, Immunohistochemistry-Paraffin: 1:10 - 1:50, Flow (Cell Surface), Immunohistochemistry-Frozen: 1:20
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of amino acids 684-701 of human TLR7 (NP_057646).
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: toll like receptor 7
• Database Link:
  NP_057646
  Q9NYK1
• Background: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.
• Synonyms: TLR7-like
• Note: Flow Cytometry: (Cell Surface): see Wong et al, 2007 for details Immunohistochemistry-Frozen: (1:20) (see product citation, Chen et al., 2005)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway