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Caspase 8 (CASP8) Rabbit Polyclonal Antibody

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SKU
TA336325
Rabbit Polyclonal active/cleaved Caspase 8 Antibody
Size:
50 ul
Conjugation:
Unconjugated
  $585.00
5 Days*
Bulk/Customize

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View other "Caspase 8 or NM_033355" antibodies

Specifications
Specifications
Product Data
Application FC, ICC/IF, IHC, IP, Simple Western, WB
Recommended Dilution Western Blot: 1:1000-1:2000, Immunohistochemistry: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:50-1:200, Immunohistochemistry-Paraffin: 1:1000-1:5000, Immunohistochemistry-Frozen: 1:10-1:500, Flow Cytometry, Simple Western
Reactivity Gerbil, Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Recombinant catalytically active human Caspase-8 protein was used as immunogen.
Buffer Store at -20C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Whole antisera
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 55.4 kDa
Gene Name caspase 8
Database Link
Background Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.
Synonyms ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Reference Data
Protein Categories Cancer: Gastrointestinal, Cytokines, Enzyme: Peptidases, Immune system diseases, Intracellular Proteins
Protein Families Druggable Genome, Protease
Protein Pathways Alzheimer's disease, Apoptosis, Huntington's disease, NOD-like receptor signaling pathway, p53 signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Viral myocarditis
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.