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NPC2 Rabbit Polyclonal Antibody

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SKU
TA332678
Rabbit anti-NPC2 Polyclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $410.00
3 Weeks*
Bulk/Customize

Frequently Bought Together (2)

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LY401935 Transient overexpression lysate of Niemann-Pick disease, type C2 (NPC2) (as WB positive control) 100 ug
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View other "NPC2 or NM_006432" antibodies

Specifications
Specifications
Product Data
Application ELISA, ICC/IF, IHC, WB
Recommended Dilution WB,1:500 - 1:2000
IHC-P,1:50 - 1:200
IF/ICC,1:50 - 1:200
ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Buffer Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20℃. Avoid freeze / thaw cycles.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 17kDa
Gene Name NPC intracellular cholesterol transporter 2
Database Link
Background This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.
Synonyms EDDM1; HE1
Reference Data
Protein Categories Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
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Documents
Resources

file-alt Citations

Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease
Hede, Christiansen, Heegaard et al
J Neurochem (2021) 156 (3), 290-308 DOI: 10.1111/jnc.14982
Cited by 23
AI Summary: In this study, OriGene’s TrueClone NPC2 cDNA (Cat# RC201307) was used to generate recombinant NPC2 protein for transfection experiments, enabling the evaluation of gene therapy strategies targeting the blood-brain barrier in Niemann Pick type C2 disease.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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