CD42a (GP9) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Buffer | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 19kDa |
| Gene Name | glycoprotein IX platelet |
| Database Link | |
| Background | This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. |
| Synonyms | CD42a; GPIX |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, CD Markers, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | ECM-receptor interaction, Hematopoietic cell lineage |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Deficiency of platelet adhesion molecule CD226 causes megakaryocyte development and platelet hyperactivity
Zhang, Ding, Jiang et al
FASEB J. (2020) 34 (5), 6871-6887 DOI: 10.1096/fj.201902142R
Zhang, Ding, Jiang et al
FASEB J. (2020) 34 (5), 6871-6887 DOI: 10.1096/fj.201902142R
AI Summary: OriGene products, specifically the platelet glycoprotein Ibα and GPIX antibodies, were used in this study to detect key platelet proteins by immunoblotting, aiding the analysis of megakaryocyte development and platelet function in CD226-deficient mice.
Snippet: Mouse PRP was collected and lysed in a RIPA buffer. Total cellular proteins were quantified with a BCA protein assay kit (Pierce, Rockford, USA). Cell lysates were loaded into an SDS-PAGE gel, and the proteins were then transferred onto a nitrocellulose membrane. After blocking with 5% milk, proteins were probed with primary antibodies overnight at 4°C. Platelet glycoprotein (GP) Ibα and GPIⅩ anti...
Showing 1-1 of 1 papers.
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