GCLM Rabbit Polyclonal Antibody

CAT#: TA332604

Rabbit anti-GCLM Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using GCLM antibody.

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  Immunofluorescence analysis of U20S cell using GCLM antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human GCLM
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 274
• Gene Name: glutamate-cysteine ligase modifier subunit
• Database Link:
  NP_002052
  Entrez Gene 14630 MouseEntrez Gene 29739 RatEntrez Gene 2730 Human
  UniProt ID P48507
• Background: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
• Synonyms: GLCLR

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism, Metabolic pathways