S adenosylhomocysteine hydrolase (AHCY) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, ICC/IF, WB |
|---|---|
| Recommended Dilution | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Buffer | Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 48kDa |
| Gene Name | adenosylhomocysteinase |
| Database Link | |
| Background | S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | adoHcyase; SAHH |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Cysteine and methionine metabolism, Metabolic pathways, Selenoamino acid metabolism |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model
Akpa, Kleo, Oker et al
BMC Cancer (2020) 20 (1), 427 DOI: 10.1186/s12885-020-06937-8
Akpa, Kleo, Oker et al
BMC Cancer (2020) 20 (1), 427 DOI: 10.1186/s12885-020-06937-8
Cited by 7
AI Summary: In this study, the OriGene AHCY antibody (TA332593) was used to detect AHCY protein expression, helping to demonstrate that copy number gains of AHCY are associated with acquired resistance to DZNep-mediated apoptosis in B-cell lymphoma cells.
Snippet: Histone 3 ✓ Cell Signaling Technology 96C10 Cleaved PARP ✓ Cell Signaling Technology Asp214 AHCY ✓ ✓ OriGene TA332593 Secondary antibody Anti-rabbit HRP-conjugated ✓ GE Healthcare NA934V Anti-mouse HRP-conjugated ✓ Agilent P0447;Histone 3 ✓ Cell Signaling Technology 96C10 Cleaved PARP ✓ Cell Signaling Technology Asp214 AHCY ✓ ✓ OriGene TA332593 Secondary antibody Anti-rabbit HRP-conjugated ✓ GE Healthcare NA934V
Epigenetic-mediated apoptosis in aggressive B-cell lymphomas
Akpa
Thesis (2020)
Akpa
Thesis (2020)
Snippet: Page 1. Epigenetic-mediated apoptosis in aggressive B-cell lymphomas Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry and Pharmacy of Freie Universitat Berlin by;Cleaved PARP ✓ Cell Signaling Technology 9541S AHCY ✓ ✓ OriGene TA332593
Showing 1-2 of 2 papers.
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