Major Basic Protein (PRG2) Rabbit Polyclonal Antibody

CAT#: TA332544

Rabbit anti-PRG2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PRG2 antibody.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PRG2
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 222
• Gene Name: proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
• Database Link:
  NP_002719
  Entrez Gene 19074 MouseEntrez Gene 5553 Human
  UniProt ID P13727
• Background: The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: BMPG; MBP; MBP1

Reference Data

• Protein Families: Secreted Protein
• Protein Pathways: Asthma