CD11a (ITGAL) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, ICC/IF, IHC, WB |
|---|---|
| Recommended Dilution | WB,1:100 - 1:500 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Buffer | Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 129kDa |
| Gene Name | integrin subunit alpha L |
| Database Link | |
| Background | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | CD11A; LFA-1; LFA1A |
| Reference Data | |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Viral myocarditis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Arginase-2 enhances monocyte-endothelial interaction through regulation of integrin and membrane receptor expression: role in atherogenesis
Ajalbert, Yao, Rohrer et al
J Biomed Sci (2026) 33 (1) DOI: 10.1186/s12929-026-01278-3
Ajalbert, Yao, Rohrer et al
J Biomed Sci (2026) 33 (1) DOI: 10.1186/s12929-026-01278-3
AI Summary: In this study, OriGene’s ITGAL antibody (TA332416) was used for immunofluorescence analysis to assess integrin αL expression in monocytes, helping to demonstrate how ARG2 regulates monocyte-endothelial interactions relevant to atherogenesis.
Snippet: ITGAL (sc-374172, Santa Cruz)WB 1:750ITGAL (TA332416, Origene)IF 1:100ITGA4 (sc-365569, Santa Cruz)WB 1:750
Showing 1-1 of 1 papers.
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