ITCH Rabbit Polyclonal Antibody

CAT#: TA330480

Rabbit Polyclonal Anti-ITCH Antibody

Product Images

WB Suggested Anti-ITCH Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: COLO205 cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-ITCH antibody: synthetic peptide directed towards the N terminal of human ITCH. Synthetic peptide located within the following region: QLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENR
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 99 kDa
• Gene Name: itchy E3 ubiquitin protein ligase
• Database Link:
  NP_113671
  Entrez Gene 83737 Human
  UniProt ID Q96J02
• Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
• Synonyms: ADMFD; AIF4; AIP4; dJ468O1.1; NAPP1
• Note: Immunogen sequence homology: Human: 100%; Pig: 93%; Rabbit: 93%; Guinea pig: 93%; Dog: 92%; Rat: 86%; Horse: 86%; Bovine: 86%

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Endocytosis, Ubiquitin mediated proteolysis