ASCL1 Rabbit Polyclonal Antibody

CAT#: TA330265

Rabbit Polyclonal Anti-ASCL1 Antibody

Product Images

WB Suggested Anti-ASCL1 Antibody Titration: 1.25ug/ml; Positive Control: Human Thymus

• 

  Human kidney

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB, IHC
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-ASCL1 antibody: synthetic peptide directed towards the N terminal of human ASCL1. Synthetic peptide located within the following region: QSAQQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELM
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: achaete-scute family bHLH transcription factor 1
• Database Link:
  NP_004307
  Entrez Gene 429 Human
  UniProt ID P50553
• Background: ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers.
• Synonyms: ASH1; bHLHa46; HASH1; MASH1
• Note: Immunogen sequence homology: Pig: 100%; Human: 100%; Bovine: 100%; Guinea pig: 100%; Dog: 92%; Rat: 92%; Mouse: 92%; Rabbit: 92%

Reference Data

• Protein Families: Druggable Genome, Transcription Factors