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Scnn1a Rabbit Polyclonal Antibody

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SKU
TA329045
Rabbit polyclonal Anti-ENaCalpha (extracellular)
Size:
50 ul
Conjugation:
Unconjugated
  $1,145.00
3 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 1:200-1:2000
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)EELDRITEQTLFD, corresponding to amino acid residues 173-185 of rat ENaCa. Extracellular loop.
Buffer Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Gene Name sodium channel epithelial 1 alpha subunit
Database Link
Background The DEG/ENaC family consists of Na+ selective channels. They are characterized by 2 transmembrane domains with a large extracellular loop, important for channel activity and intracellular N-and C-termini which are important for channel gating and for interacting with regulatory proteins respectively. ENaC is localized to the apical side of polarized epithelial cells like those in the kidney, lung, and distal colon and is responsible for maintaining proper Na+ balance. This channel is formed by oligomerization of three subunits, α, β, and γ usually with the α2β1γ1 combination. In addition, the a subunit which is essential for channel activity undergoes phosphorylation in its C-terminal by SGK1 (serum and glucocorticoid-induced kinase 1) which is known to activate the channel at the plasma membrane. Pseudohypoaldosteronism type 1 (PHA-1) has an early onset and is depicted by severe dehydration, hyponatremia and hyperkalemia. One form of the pathology is characterized by mutations in α, β, and γ subunits. The severity of the diseases depends on the loss of activity of the channel.
Synonyms Alpha-ENaC; Alpha-NaCH; BESC2; ENaCa; ENaCalpha; FLJ21883; SCNEA; SCNN1
Reference Data
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Documents
Resources

file-alt Citations

Clinical Application of Epithelial Sodium Channel (ENaC) as a Biomarker for Arterial Hypertension
García-Rubio, Martínez-Vieyra, de la Mora et al
Biosensors (Basel) (2022) 12 (10) DOI: 10.3390/bios12100806
Cited by 7
Snippet: d transferred onto nitrocellulose membranes using a semidry system (Thermo Electron Co., Milford, MA, USA). Membranes were incubated with α-ENaC rabbit polyclonal antibody (1:200;catalog: TA329045;OriGene Technologies Inc., Rockville, MD, USA) or an anti-mouse GAPDH antibody (1:500;cat. sc-47724;Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) as a loading control at 4 °C overnight. The
FigureFigureFigure
WB
Showing 1-1 of 1 papers.
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