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Grin3b Rabbit Polyclonal Antibody

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SKU
TA328844
Rabbit Polyclonal Anti-NMDA Receptor 3B (GluN3B) (extracellular)
Size:
50 ul
Conjugation:
Unconjugated
  $1,145.00
2 Weeks*
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Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)HVSRHFKVWSLRRD, corresponding to amino acid residues 363-376 of rat NMDAR3B. Extracellular, N-terminus.
Buffer Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Gene Name glutamate ionotropic receptor NMDA type subunit 3B
Database Link
Background The NMDA receptors (NMDARs) are members of the glutamate receptor family of ion channels that also include the AMPA and Kainate receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neuronal depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinsonâ??s and Alzheimerâ??s disease. The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.
Synonyms NMDAR3B; NR3B
Reference Data
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Documents
Resources

file-alt Citations

Persistent neuroadaptations in the nucleus accumbens core accompany incubation of methamphetamine craving in male and female rats
Funke, Hwang, Wunsch et al
eNeuro (2023) 10 (3) DOI: 10.1523/ENEURO.0480-22.2023
AI Summary: OriGene products GluN3A (TA328843) and GluN3B (TA328844) antibodies were used in this study to assess NMDA receptor subunit expression in the nucleus accumbens core, contributing to the investigation of synaptic adaptations associated with persistent methamphetamine craving in rats.
Snippet: icals, NB300-105 (Novus Product Datasheet, v20.1 Updated 9/14/16);GluN2B (1:1000), rabbit, Cell Signaling Technology, 14 544 (Pietrogrande et al., 2019;Yang et al., 2020);GluN3A (1:200), rabbit, OriGene, TA328843 (OriGene Product Information);GluN3B (1:200), rabbit, OriGene, TA328844 (OriGene Product Information), and GAPDH (1:5000), mouse, Calbiochem, CB1001. The following horseradish perox
WB
GluN3-containing NMDA receptors in the rat nucleus accumbens core contribute to incubation of cocaine craving
Christian, Stefanik, Bean et al
J Neurosci (2021) 41 (39), 8262-8277 DOI: 10.1523/JNEUROSCI.0406-21.2021
AI Summary: OriGene’s GluN3A (TA328843) and GluN3B (TA328844) antibodies were used in this study to detect and analyze the expression of GluN3 subunits, enabling the authors to investigate their roles in NMDA receptor plasticity underlying incubation of cocaine craving in rats.
Snippet: 14544 (Pietrogrande et al., 2019;Yang et al., 2020);GluN3A (1:200), rabbit, OriGene, TA328843 256 (OriGene Product Information);GluN3B (1:200), rabbit, OriGene, TA328844 (OriGene Product 257 Information). 258 2-Photon Ca2+ imaging
Showing 1-2 of 2 papers.
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