Uts2r Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
| Reactivity | Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide (C)RPLDTVQRSKGYRK, corresponding to amino acid residues 154-167 of rat UTIIR. 2nd intracellular loop. |
| Buffer | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
| Purification | Affinity purified on immobilized antigen. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | urotensin 2 receptor |
| Database Link | |
| Background | Urotensin II is a very powerful vasoconstrictive substance. The human Urotensin II receptor (UTIIR) was originally isolated as an orphan receptor (GPR14) in neural and sensory tissues. Urotensin II is expressed in various human tissues such as CNS, skeletal muscle, smooth muscle, pancreas, and heart. Binding of Urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.Recently, evidence has accumulated indicating that Urotensin II is also expressed in various kinds of tumor cells such as of adrenal tumors and neuroblastomas. In those cells Urotensin II was reported to stimulate cell growth. |
| Synonyms | GPR14; UR-II-R; UTR; UTR2 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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