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Drd5 Rabbit Polyclonal Antibody

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SKU
TA328802
Rabbit Polyclonal Anti-D5 Dopamine Receptor (extracellular)
Size:
50 ul
Conjugation:
Unconjugated
  $1,145.00
3 Weeks*
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Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide EEGWELEGRTENC, corresponding to amino acid residues 199-211 of rat D5 dopamine receptor. 2nd extracellular loop.
Buffer Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Gene Name dopamine receptor D5
Database Link
Background The D5 Dopamine Receptor (D5 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson’s disease and schizophrenia. All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes). The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity. The D5 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex, hippocampus and striatum. In the periphery the D5 receptor has been localized in the adrenal cortex, kidney and intestinal tract. The exact physiological function of the D5 receptor subtype remains poorly understood. Studies with D5 receptor knock out mice have shown no overt alterations in locomotor or cognitive functions. However, knock out mice do develop severe hypertension suggesting a role of D5 receptor in the modulation of neuronal pathways regulating blood pressure responses.
Synonyms DBDR; DRD1B; DRD1L2; MGC10601
Reference Data
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Documents
Resources

file-alt Citations

Alteration of the Dopamine Receptors' Expression in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant (Naked-Ataxia (NAX)) Mouse
Mehdizadeh, Ashtari, Jiao et al
Int J Mol Sci (2020) 21 (8) DOI: 10.3390/ijms21082914
Cited by 11
AI Summary: OriGene products contributed to this study by providing the primary antibodies against dopamine receptors—anti-Drd1 (TA328798), anti-Drd2 (TA328800), anti-Drd3 (TA328800), anti-DRD4 (TA321202), and anti-Drd5 (TA328802)—which were used for immunohistochemistry and Western blot analyses to assess dopamine receptor expression in mouse cerebellum.
Snippet: … D1: rabbit polyclonal anti–D1 dopamine receptor (TA328798, anti–Drd1, diluted 1:1000;OriGene Biotech Co., Rockville, MD, USA);D2: rabbit polyclonal anti–D2 dopamine receptor (TA328800, anti–Drd2, diluted 1:1000;OriGene Biotech Co., Rockville, MD, USA), produced against recombinant rat dopamine receptor 2 (DR2);D3: rabbit polyclonal anti–D3 dopamine receptor (TA328800, anti–Drd3, diluted 1:1000;OriGene Biotech Co., Rockville, MD, USA), produced against recombinant rat dopamine receptor 3 (DR3);D4: rabbit polyclonal anti–D4 dopamine receptor (TA321202, anti–DRD4, diluted 1:1000;OriGene Biotech Co., Rockville, MD, USA), produced against recombinant rat dopamine receptor D4 (DRD4);and D5: rabbit polyclonal anti–D5 dopamine receptor (TA328802, anti–Drd5, diluted 1:1000;OriGene Biotech Co., Rockville, MD, USA), produced against recombinant rat dopamine receptor 5 (DR5)
WB IHC
Showing 1-1 of 1 papers.
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