Trpc6 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | WB: 1:200-1:2000; FC: 1:50-1:600 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide (C)DNVKYYNLARIKWD, corresponding to amino acid residues 573-586 of rat TRPC6. 2nd extracellular loop. |
| Buffer | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
| Purification | Affinity purified on immobilized antigen. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | transient receptor potential cation channel, subfamily C, member 6 |
| Database Link | |
| Background | The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals, about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels.The TRPC subfamily consists of seven proteins named TRPC1 to 7 which can be further divided into four subgroups based on their sequence homology and functional similarities: 1. the TRPC1 2. TRPC4 and TRPC5 3. TRPC3, TRPC6, TRPC7 4. TRPC22,5. They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues.TRPC6 can form heterotetramers with TRPC3 and TRPC7. It is primarily expressed in brain, lung and muscle. High levels of expression of the channel were also found in human platelets. Recently it was reported that TRPC6 is also expressed in the kidney where a mutated channel has been implicated in kidney failure disease. |
| Synonyms | FLJ11098; FLJ14863; FSGS2; TRP6 |
| Note | This antibody was tested in live cell imaging. Please see IF/ICC data for detail. |
| Reference Data | |
| Protein Categories | Membrane Proteins |
Reviews
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Citations
The store-operated Ca2+ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2
Nieto-Felipe, Sanchez-Collado, Jardin et al
J Biol Chem (2023) 299 (2), 102882 DOI: 10.1016/j.jbc.2023.102882
Nieto-Felipe, Sanchez-Collado, Jardin et al
J Biol Chem (2023) 299 (2), 102882 DOI: 10.1016/j.jbc.2023.102882
Cited by 14
AI Summary: In this study, the OriGene rabbit polyclonal anti-TRPC6 antibody (catalog number: TA328771) was used to detect TRPC6 protein, contributing to the analysis of protein expression relevant to the investigation of Orai1α-mediated NF-κB activation.
Snippet: a. PKCβ shRNA (catalog number: sc-29450-SH;from Santa Cruz Biotechnology). Rabbit polyclonal anti-TRPC6 antibody (catalog number: TA328771, epitope: amino acid residues 573–586 of TRPC6) was from Origene Technologies, Inc. Rabbit monoclonal anti-PKCβ2 antibody (clone Y125, epitope located in the region near the C terminus of PKCβ2;catalog number: ab32026) and rabbit monoclonal anti-Orai3 an
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels' Activation in Breast Cancer Cells
López, Siegfried, Cantonero et al
Cancers (Basel) (2021) 13 (7) DOI: 10.3390/cancers13071670
López, Siegfried, Cantonero et al
Cancers (Basel) (2021) 13 (7) DOI: 10.3390/cancers13071670
Cited by 20
AI Summary: In this study, OriGene’s ppFurin cDNA (Cat# SC123411) and Furin cDNA (Cat# SC121332) were used to generate stable cell lines and perform transfection experiments, enabling the authors to investigate the effects of Furin inhibition on calcium entry and malignant behavior in breast cancer cells.
Furin Prodomain Ppfurin Enhances Soce Through trpc6 Activation in Breast Cancer Cells
López, Siegfried, Cantonero et al
Preprints (2020) 1 DOI: 10.20944/preprints202008.0441.v1
López, Siegfried, Cantonero et al
Preprints (2020) 1 DOI: 10.20944/preprints202008.0441.v1
Cited by 1
Snippet: … Article 1 Furin prodomain ppFurin enhances SOCE through TRPC6 activation in 2 breast cancer cells 3 4 Jose J. …Rabbit polyclonal anti-TRPC6 antibody (catalog number: TA328771, corresponding to amino acid residues 573-586 of rat TRPC6, 2nd extracellular loop) was from Origene (Rockville, MD, USA). …
Stanniocalcin 2 Regulates Non-capacitative Ca2+ Entry and Aggregation in Mouse Platelets
López, Gómez-Gordo, Cantonero et al
Front Physiol (2018) 9, 266 DOI: 10.3389/fphys.2018.00266
López, Gómez-Gordo, Cantonero et al
Front Physiol (2018) 9, 266 DOI: 10.3389/fphys.2018.00266
Cited by 11
AI Summary: In this paper, OriGene products—including anti-Orai3 (Cat# TA322352), anti-TRPC3 (Cat# TA322366), and anti-TRPC6 (Cat# TA322368) antibodies—were used for Western blot analysis to assess the expression of calcium channels in mouse platelets, helping to reveal that Orai3 expression is enhanced in STC2-deficient mice.
Showing 1-4 of 4 papers.
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