Cacnb2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:200-1:2000 |
| Reactivity | Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide (C)HEHVDRYVPHREHNHRE, corresponding to amino acid residues 571-587 of rat CavÃ?2. Intracellular, C-terminus. |
| Buffer | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
| Purification | Affinity purified on immobilized antigen. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | calcium voltage-gated channel auxiliary subunit beta 2 |
| Database Link | |
| Background | Voltage-dependent Ca2+ channels are a family of membrane proteins that allow cells to couple electrical activity to intracellular Ca2+ signaling. Voltage-gated Ca2+ channels are classified as T, L, N, P, Q and R, and are distinguished by their sensitivity to pharmacological blocks, single-channel conductance kinetics, and voltage-dependence.On the basis of their voltage activation properties, voltage-gated Ca2+ subtypes can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels. The activity of the channel pore is modulated by 4 tightly-coupled subunits: an intracellular Ã? subunit; a transmembrane ? subunit; and a disulphide-linked complex of a2 and d subunits. There are four distinct Ã? subunits: Ã?1, Ã?2, Ã?3 and Ã?4. There are 4 splice variants of the Ã?2 subunit: Ã?2a, Ã?2b, Ã?2c and Ã?2d. Ã?2a and Ã?2b are expressed in heart, aorta and brain, and are 606- and 632-residue proteins, respectively. Ã?2c and Ã?2d (655 and 604 residues, respectively) are expressed in brain, and recent studies show beta-2c to be also expressed in heart. All splice variants differ in their N-terminal regions. |
| Synonyms | CAB2; CACNLB2; CAVB2; FLJ23743; MYSB |
| Reference Data | |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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