TRPM7 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide CKRRKKDKTSDGPKLFLTEE, corresponding to amino acid residues 1146-1165 of human TRPM7. Intracellular, C-terminus. |
| Buffer | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
| Purification | Affinity purified on immobilized antigen. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | transient receptor potential cation channel subfamily M member 7 |
| Database Link | |
| Background | TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells. The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the six TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular. According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC (canonical), TRPV (vanilloid) and TRPM (melastatin). To date, three extra subfamilies are also considered to belong to the TRP family; the TRPA, TRPML, and the TRPP. The TRPM subfamily consists of eight members, TRPM1 to TRPM8, which also can be further subdivided into four subgroups based on their sequence homology: (1)TRPM1 and TRPM3 (2) TRPM6 and TRPM7 (3) TRPM4 and TRPM5 (4) TRPM2 and TRPM8. TRPM7 and TRPM6 are involved in Mg2+ homeostasis and are unique among the TRP family members, possessing a functional kinase domain at their C-terminus. Although the kinase is not necessary to the function of the channel it may have a role in modulating the activation of the channel. Recent work demonstrated that TRPM7 is a critical mediator of anoxic cell death. |
| Synonyms | ALSPDC; CHAK; CHAK1; LTrpC-7; LTRPC7; TRP-PLIK |
| Reference Data | |
| Protein Categories | Enzyme: Kinases, Intracellular Proteins, Membrane Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome, Ion Channels: Transient receptor potential, Protein Kinase, Transmembrane |
Reviews
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Citations
Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis
Yee, Kazi, Li et al
Biol Open (2015)
Yee, Kazi, Li et al
Biol Open (2015)
Cited by 54
AI Summary: OriGene Technologies contributed to this study by providing anti-human TRPM7 and anti-human GAPDH antibodies, which were used to assess protein expression levels in pancreatic cancer tissues and cells.
Snippet: Biotrace;PALL, Pensacola, Florida, USA), blocked in 5% non-fat dry milk, and then incubated overnight at 4°C with anti-human TRPM7 (rabbit polyclonal, 1:750 dilution) and anti-human GAPDH (mouse monoclonal, 1:2,500 dilution) antibodies (OriGene Technologies ... Cite SaveSaving
Showing 1-1 of 1 papers.
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