CHRM1 Rabbit Polyclonal Antibody
$1,145.00
3 Weeks*
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide (C)RKIPKRPGSVHRTPSR, corresponding to amino acid residues 443-458 of human M1 Muscarinic Receptor. Intracellular, C-terminus. |
| Buffer | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
| Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
| Purification | Affinity purified on immobilized antigen. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Gene Name | cholinergic receptor muscarinic 1 |
| Database Link | |
| Background | The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein coupled receptors. Five subtypes of muscarinic receptors have been cloned and named m1-m5. The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues. Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control. They also participate in learning and memory processing. The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors are also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves. The m1, m3 and m5 receptors, which are coupled to Gq/11 proteins, can protect cells from apoptosis induced by DNA damage. The signaling mechanism that mediates this anti-apoptotic response is still poorly understood. However, it was recently reported that a poly-basic motif in the C-terminus tail of the m1, m3 and m5 receptors is an essential element for the anti-apoptotic response of those receptors. |
| Synonyms | HM1; M1; M1R |
| Reference Data | |
| Protein Categories | GPCR, Membrane Proteins |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells
Liu, Lin, Chen et al
Eur Arch Otorhinolaryngol (2016)
Liu, Lin, Chen et al
Eur Arch Otorhinolaryngol (2016)
Cited by 5
AI Summary: In this study, OriGene’s rabbit anti-M1R and anti-M3R antibodies were used for immunocytochemistry and western blotting to assess the expression of muscarinic receptors in human nasal epithelial cells treated with budesonide and azelastine.
Snippet: After fixation in 4 % paraformaldehyde for 10 min, slides were rinsed three times with PBS and incubated in primary antibodies (rabbit anti-H1R, Thermo Scientific No. PA5-27817, 1:100;rabbit anti-M1R and M3R, OriGene No. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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