MITF Mouse Monoclonal Antibody [Clone ID: C5/D5]
Specifications
| Product Data | |
| Clone Name | C5/D5 |
|---|---|
| Application | IHC |
| Recommended Dilution | IHC: 1:100 - 1:500 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Buffer | This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | melanogenesis associated transcription factor |
| Database Link | |
| Synonyms | bHLHe32; CMM8; MI; WS2; WS2A |
| Note | Microphthalmia (MiTF) is a transcription factor implicated in pigmentation, bone development, and in mast cells. Various forms of MiTF exist ranging from 50 -70 kD in size. This antibody targets the 52 - 56 kD range and has been useful in identifying malignant melanoma and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%). |
| Reference Data | |
| Protein Categories | Cancer: Skin, Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Melanogenesis, Melanoma, Pathways in cancer |
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