SH2D1A Rabbit Polyclonal Antibody

CAT#: TA326947

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Rabbit anti-SH2D1A Polyclonal Antibody


Product Datasheet for 'TA326947'


USD 345.00


Availability*
3 Weeks

Size
    • 100 ul


Product images

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB 1:500 - 1:2000, IHC 1:50- 1:200, IF 1:50- 1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human SH2D1A
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1 mg/ml
Purification Affinity purification
Gene Name SH2 domain containing 1A
Background SH2D1A and SH2D1B are small, adaptor proteins with a single SH2-domain that play important signal transduction roles mediated by the signaling lymphocytic activation molecule (SLAM) family receptors . SH2D1A (also called SAP or SLAM-associated protein) is frequently mutated in patients with X-linked lymphoproliferative disease (Duncan’s disease), which is characterized by extreme susceptibility to Epstein-Barr virus; approximately 50 different SH2D1A mutations have been reported to date. The single SH2D1B gene in humans (also called EAT-2 or Ewing's sarcoma's/FLI1-activated transcript 2) is present as a pair of duplicated EAT-2A and EAT-2B genes with identical genomic organization in mouse and rat.
Synonyms DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1
Reference Data
Protein Families Druggable Genome
Protein Pathways Natural killer cell mediated cytotoxicity
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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