RAN Rabbit Polyclonal Antibody

CAT#: TA326874

RAN Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using RAN antibody.

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  Immunofluorescence analysis of HeLa cell using RAN antibody. Blue: DAPI for nuclear staining.

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  Immunofluorescence analysis of MCF-7 cell using RAN antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50 - 1:200
• Reactivities: Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human RAN
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: RAN, member RAS oncogene family
• Database Link:
  NP_006316
  Entrez Gene 19384 MouseEntrez Gene 84509 Rat
  UniProt ID P62826
• Background: Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport. During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation. In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle.
• Synonyms: ARA24; Gsp1; TC4

Reference Data

• Protein Families: Druggable Genome, Transcription Factors