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UCP1 Rabbit Polyclonal Antibody

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SKU
TA326708
Rabbit Polyclonal UCP1 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
2 Weeks*
Bulk/Customize

Frequently Bought Together (2)

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View other "UCP1 or NM_021833" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen UCP1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human UCP1 (GenBank accession.
Buffer UCP1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification UCP1 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size Predicted: 34 kDa; Observed: 36 kDa
Gene Name uncoupling protein 1
Database Link
Background The mitochondrial brown fat uncoupling protein 1 (UCP1) is a member of the family of mitochondrial anion carrier proteins (MACP) (1). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells (1). UCP1 is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat (1).
Synonyms SLC25A7; UCP
Reference Data
Protein Categories Endocrine and metabolic diseases, Membrane Proteins
Protein Families Druggable Genome
Protein Pathways Huntington's disease, PPAR signaling pathway
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Documents
Resources

file-alt Citations

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue
Song, Luo, Zhang et al
PLoS Biol. (2019) 17 (1), e2006571 DOI: 10.1371/journal.pbio.2006571
AI Summary: OriGene’s rabbit anti-mouse Oct3 antibody was used in this study to specifically detect Oct3 expression in mouse white adipose tissue, enabling the identification of Oct3 as a key norepinephrine transporter in adipocytes.
Snippet: Mouse ingWAT frozen sections were then blocked for 30 minutes in PBS containing 10% normal goat serum at RT. For Oct3 staining, sections were incubated with a rabbit anti-mouse Oct antibody (1:200;OriGene Technologies, Rockville, MD) followed by staining with a Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 (1:500;Invitrogen, Carlsbad, CA). Then, sections were st
FigureFigureFigure
IF
Showing 1-1 of 1 papers.
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