IL22 Rabbit Polyclonal Antibody

CAT#: TA326688

Rabbit Polyclonal IL-22 Antibody

Product Images

Western blot analysis of IL-22 in HeLa cell lysate with IL-22 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunocytochemistry of IL-22 in HeLa cells with IL-22 antibody at 5 ug/mL.

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  Immunofluorescence of IL-22 in HeLa cells with IL-22 antibody at 20 ug/mL.

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  Immunocytochemistry of IL-22 in HeLa cells with IL-22 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-22 antibody was raised against a 17 amino acid peptide near the center of human IL-22
• Formulation: IL-22 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-22 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 20 kDa; Observed: 25 kDa
• Gene Name: interleukin 22
• Database Link:
  NP_065386
  Entrez Gene 50929 MouseEntrez Gene 500836 RatEntrez Gene 50616 Human
  UniProt ID Q9GZX6
• Background: Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).
• Synonyms: IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa; TIFIL-23; zcyto18

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway