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ULK3 Rabbit Polyclonal Antibody

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SKU
TA326685
Rabbit Polyclonal ULK3 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
5 Days*
Bulk/Customize

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View other "ULK3 or NM_001099436" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen ULK3 antibody was raised against a 19 amino acid peptide near the center of human ULK3.
Buffer ULK3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification ULK3 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size Predicted: 52 kDa; Observed: 52 kDa
Gene Name unc-51 like kinase 3
Database Link
Background ULK3 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1). Knockout of ULK genes results in a severe defect in the autophagy pathway (2). ULK3, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK4, is highly conserved among eukaryotes (3). ULK3 has been shown to be a positive regulator of the Hedgehog signaling pathway by enhancing GLI1 and GLI2 transcriptional activity (4). Furthermore, ULK3 can also interact with SUFU, a protein required for the negative regulation of GLI proteins; this interaction blocks the autophosphorylation of ULK3 and blocks its ability to regulate the GLI proteins (5).
Synonyms DKFZp434C131; FLJ90566
Reference Data
Protein Categories Enzyme: Kinases, Intracellular Proteins
Protein Families Druggable Genome, Protein Kinase
Protein Pathways mTOR signaling pathway, Regulation of autophagy
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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