AIMP2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. |
| Buffer | AIMP2 antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | AIMP2 antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | Predicted: 35 kDa; Observed: 36 kDa |
| Gene Name | aminoacyl tRNA synthetase complex interacting multifunctional protein 2 |
| Database Link | |
| Background | AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson’s disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4). |
| Synonyms | JTV-1; JTV1; P38; PRO0992 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Stem cell - Pluripotency |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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