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TGF beta receptor associated protein 1 (TGFBRAP1) Rabbit Polyclonal Antibody

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SKU
TA326622
Rabbit Polyclonal SDHD Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
2 Weeks*
Bulk/Customize

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View other "SDHD" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD.
Buffer SDHD Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification SDHD Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name transforming growth factor beta receptor associated protein 1
Database Link
Background SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
Synonyms CBT1; CII-4; CWS3; cybS; PGL; PGL1; QPs3; SDH4
Reference Data
Protein Categories Cancer: Endocrine, Cancer: Gastrointestinal, Intracellular Proteins, Membrane Proteins
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Documents
Resources

file-alt Citations

NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly
Hou, Zhang, Jian et al
Cell Res. (2019) 29 (9), 754-766 DOI: 10.1038/s41422-019-0208-x
AI Summary: OriGene products, specifically antibodies against NDUFAB1, SDHB, and SDHD, were used in this study to detect and analyze mitochondrial respiratory complex proteins, enabling the authors to assess the effects of NDUFAB1 on mitochondrial bioenergetics and cardio-protection.
Snippet: …The antibodies for NDUFAB1, SDHB, and SDHD were from Origene, those for NDUFB8, NDUFS4, SDHA, UQCRC1, UQCRB, ATPB, ATP5A, AcK103, and lipoic acid from Abcam, and those for NDUFS1, NDUFS6, NDUFS7, UQCRFS1, COXIV, ISCU, and NFS1 from ProteinTech
WB
NDUFAB1 Protects Heart by Coordinating Mitochondrial Respiratory Complex and Supercomplex Assembly
Hou, Zhang, Jian et al
bioRxiv (2018)
Snippet: The antibodies for NDUFAB1 (TA308227), SDHB (TA351639), and SDHD (TA326622) were from Origene, those for NDUFB8 (ab110242), NDUFS4 (ab137064), SDHA (ab14715), UQCRC1 (ab110252), UQCRB (ab190360), ATPB (ab14730), and ATP5A (ab176569) from Abcam, and those for NDUFS1 (12444-1-AP), NDUFS6 (14417-1-AP), NDUFS7 (15728-1-AP), UQCRFS1 (18443-1-AP), and COXIV (11242-1-AP) from ProteinTech
Showing 1-2 of 2 papers.
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