Sod2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | 0.5ug/ml was sufficient for detection of Mn SOD in 20ug of rat brain tissue extract |
| Reactivity | Bovine, Canine, Chicken, Drosophila, Guinea Pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Rat Mn SOD |
| Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Concentration | lot specific |
| Purification | Affinity (antigen) Purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | superoxide dismutase 2, mitochondrial |
| Database Link | |
| Background | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space . SOD3 can also be distinguished by its heparin-binding capacity . |
| Synonyms | IPO-B; Mn-SOD; MNSOD; MVCD6 |
| Note | Detects a ~25kDa protein corresponding to the molecular mass of Mn superoxide dismutase (SOD) on SDS PAGE immunoblots. |
| Reference Data | |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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