Calnexin (CANX) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:2000 |
| Reactivity | Bovine, Chicken (weak), Dog, Drosophila (weak), Guinea Pig, Hamster, Human, Monkey, Mouse, Pig, Quail, Rabbit, Rat, Sheep, Xenopus (weak) |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Dog Calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues. |
| Buffer | PBS pH7.2, 50% glycerol, 0.09% sodium azide |
| Concentration | lot specific |
| Purification | Protein A Purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | calnexin |
| Database Link | |
| Background | Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 . It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail . Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention , calnexin has positively charged cytosolic residues that do the same thing . Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulitsubunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans . Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin . |
| Synonyms | CNX; IP90; P90 |
| Note | Detects ~90kDa. |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Antigen processing and presentation |
Reviews
Documents
| Product Manuals |
| FAQs |
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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