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GOT2 Rabbit Polyclonal Antibody

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SKU
TA325088
GOT2 Antibody (N-term)
Size:
400 ul
Conjugation:
Unconjugated
  $645.00
2 Weeks*
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Specifications
Specifications
Product Data
Application FC, WB
Recommended Dilution WB:1/1000, FC:1/10-50
Reactivity Human (Predicted: Mouse, Rat)
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This GOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human GOT2.
Specificity This GOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human GOT2.
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Concentration lot specific
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size 47.5 kDa
Gene Name glutamic-oxaloacetic transaminase 2
Database Link
Background Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
Synonyms KAT4; KATIV; mitAAT
Reference Data
Protein Families Stem cell - Pluripotency
Protein Pathways Alanine, Arginine and proline metabolism, aspartate and glutamate metabolism, Cysteine and methionine metabolism, Metabolic pathways, Phenylalanine, Phenylalanine metabolism, tyrosine and tryptophan biosynthesis, Tyrosine metabolism
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Documents
Resources

file-alt Citations

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity
Hickman, Choi, Whiteman et al
PLoS One (2022) 17 (5), e0266980 DOI: 10.1371/journal.pone.0266980
Cited by 33
AI Summary: OriGene’s rabbit anti-human GOT-2 polyclonal antibody (catalog #TA325088) was used for Western blot detection of GOT2 expression, enabling assessment of transgene expression and functional analysis in the study.
Snippet: … Aberrant GPC3 expression is implicated in tumorigenesis [30–32], and GPC3-positive cancers including hepatocellular carcinomas (HCC), are characterized by a highly metabolic and immunosuppressive landscape [33], and exhaustion is a common feat;Western blot antibodies for GOT2 detection were rabbit anti-human GOT-2 polyclonal antibody (Origene, catalog #TA325088) and HRP-conjugated AffiniPure Goat anti-rabbit IgG (ThermoFisher, catalog #G-21234). …
FigureFigureFigure
WB IHC
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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