Caspase 8 (CASP8) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | FC, WB |
|---|---|
| Recommended Dilution | WB:1/2000, FC:1/10-50 |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human CASP8. |
| Specificity | This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human CASP8. |
| Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 55.4 kDa |
| Gene Name | caspase 8 |
| Database Link | |
| Background | CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. |
| Synonyms | FLICE; MACH; MCH5; MGC78473 |
| Reference Data | |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Alzheimer's disease, Apoptosis, Huntington's disease, NOD-like receptor signaling pathway, p53 signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Viral myocarditis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Tropical lichen, Dirinaria consimilis, induces ROS-mediated activation of MAPKs and triggers caspase cascade mediated apoptosis in brain and cervical cancer cells
Shendge, Panja, Mandal
Mol Cell Biochem (2021)
Shendge, Panja, Mandal
Mol Cell Biochem (2021)
Cited by 7
AI Summary: In this study, OriGene products—specifically anti-Bax, anti-BID, anti-caspase-3, anti-caspase-8, anti-caspase-9, anti-PARP, and anti-β-actin antibodies—were used for western blotting to analyze apoptosis-related protein expression in brain and cervical cancer cells treated with Dirinaria consimilis extract.
Showing 1-1 of 1 papers.
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