DIABLO Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 1000-5000 WB positive control: Lncap, SKOV3, MCF7 and 293T cells IHC: 100-300 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 56-239 amino acids of human diablo, IAP-binding mitochondrial protein |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 27 kDa |
| Gene Name | diablo IAP-binding mitochondrial protein |
| Database Link | |
| Background | This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis; and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene; with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart; liver; kidney; spleen; prostate and ovary. Low in brain; lung; thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. |
| Synonyms | DFNA64; SMAC |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
| Protein Families | Transmembrane |
Reviews
Documents
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| FAQs |
| SDS |
Citations
MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1
Liang, Liao, Li et al
Cell Commun. Signal (2018) 16 (1), 30 DOI: 10.1186/s12964-018-0244-z
Liang, Liao, Li et al
Cell Commun. Signal (2018) 16 (1), 30 DOI: 10.1186/s12964-018-0244-z
AI Summary: OriGene products contributed to this study by providing antibodies against β-actin, HSP90, HSP60, SMAC, and Apaf-1, which were used for protein detection and analysis in the investigation of miR-644a's role in hepatocellular carcinoma cell apoptosis.
Snippet: against HSF1, caspase 3, caspase 9, BAD, Bcl-2, Bcl-xL, BIM and BID were purchased from Santa Cruz (Dallas, Texas, USA). Antibodies against β-actin, HSP90, HSP60, SMAC and Apaf-1 were purchased from Origene (Rockville, MD, USA). Quantitative reverse transcription polymerase chain reaction (qRT-PCR) Total RNA was extracted from HCC cells and tissues with TRIzol (Thermofisher Inc., Grand Island, N
Showing 1-1 of 1 papers.
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