Nebulin (NEB) Rabbit Polyclonal Antibody

SKU TA324106

Anti-NEB Rabbit Polyclonal Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 50-200; Positive control: Human lung cancer; Predicted cell location: Cytoplasm
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 118-132 amino acids of human nebulin
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: nebulin
• Database Link:
  NP_004534
  P20929
• Background: This gene encodes nebulin; a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates; nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-; species-;and developmental stage-specific. Of the 183 exons in the nebulin gene; at least 43 are alternatively spliced; although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin; the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy.
• Synonyms: NEB177D; NEM2

Reference Data

• Protein Families: Druggable Genome