CDK6 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: K562 cell lysate IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 13-300 amino acids of Human Cyclin-dependent kinase 6 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 37 kDa |
| Gene Name | cyclin-dependent kinase 6 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28; and Schizosaccharomyces pombe cdc2; and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase; which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase; as well as CDK4; has been shown to phosphorylate; and thus regulate the activity of; tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants; encoding the same protein; have been identified. |
| Synonyms | MCPH12; PLSTIRE |
| Reference Data | |
| Protein Categories | Enzyme: Kinases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis
Liang, Liao, Zhang et al
J. Exp. Clin. Cancer Res. (2017) 36 (1), 64 DOI: 10.1186/s13046-017-0537-x
Liang, Liao, Zhang et al
J. Exp. Clin. Cancer Res. (2017) 36 (1), 64 DOI: 10.1186/s13046-017-0537-x
AI Summary: In this study, OriGene’s CyclinD1, CDK6, and β-actin antibodies were used to analyze protein expression levels, contributing to the investigation of cell cycle regulation and validation of experimental results in pancreatic cancer research.
Snippet: HSF1, Ki-67, caspase 3, caspase 8, Bax, Bcl-2, SMAC and XIAP antibodies were purchased from Santa Cruz Biotechnology (Dallas, TX, USA). CyclinD1, CDK6 and β-actin antibodies were purchased from Origene (Rockville, MD, USA). ... All 7 versions Cite SaveSaving
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