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BRCA2 Rabbit Polyclonal Antibody

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SKU
TA323750
Anti-BRCA2 Rabbit Polyclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $305.00
2 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application IHC
Recommended Dilution IHC: 25-100
Positive control: Human lung cancer
Predicted cell location: Nucleus
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 110-124 amino acids of Human Breast cancer type 2 susceptibility protein
Buffer PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 384 kDa
Gene Name BRCA2, DNA repair associated
Database Link
Background Inherited mutations in BRCA1 and this gene; BRCA2; confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability; specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif; and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene; as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Synonyms BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11
Reference Data
Protein Categories Cancer: Bladder, Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cardiovascular diseases, Cytokines, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Homologous recombination, Pancreatic cancer, Pathways in cancer
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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