ABCA4 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 50-200 Positive control: Human cervical cancer Predicted cell location: Membrane, Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 2260-2273 amino acids of human ATP-binding cassette, sub-family A (ABC1), member 4 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | ATP binding cassette subfamily A member 4 |
| Database Link | |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1; MDR/TAP; MRP; ALD; OABP; GCN20; White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells; indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease; a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19; cone-rod dystrophy type 3; early-onset severe retinal dystrophy; fundus flavimaculatus; and macular degeneration age-related 2. |
| Synonyms | ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19; STGD; STGD1 |
| Reference Data | |
| Protein Categories | Membrane Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | ABC transporters |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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