PLAUR Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: A549 cells IHC: 50-200 Positive control: Human lung cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 23-305 amino acids of human plasminogen activator, urokinase receptor |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 37 kDa |
| Gene Name | plasminogen activator, urokinase receptor |
| Database Link | |
| Background | This gene encodes the receptor for urokinase plasminogen activator and; given its role in localizing and promoting plasmin formation; likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However; a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. |
| Synonyms | CD87; U-PAR; UPAR; URKR |
| Reference Data | |
| Protein Categories | CD Markers, Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Complement and coagulation cascades |
Reviews
Documents
| Product Manuals |
| FAQs |
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Citations
Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions
Stronati, Palone, Negroni et al
Front Immunol (2019) 10, 939 DOI: 10.3389/fimmu.2019.00939
Stronati, Palone, Negroni et al
Front Immunol (2019) 10, 939 DOI: 10.3389/fimmu.2019.00939
AI Summary: OriGene contributed to this study by providing the anti-PLAUR antibody, which was used to assess the expression of PLAUR protein involved in extracellular matrix remodeling during intestinal mucosal healing.
Snippet: Proteins were transferred in polyvinylidene fluoride membrane (Bio-Rad) and blocked with TBS-T (Tris-buffered saline with Tween-20) containing 5% non-fat dry milk. Anti-MMP9 (1:1,000;NovusBio), anti-VTN (1:1,000;NovusBio), anti-COL3A1 (1:1,000;ThermoScientific), anti-TIMP1 (1:1,000;Bioss), anti-PLAUR (1:1,000;Origene), and anti-β-actin (1:5,000;Sigma) antibodies were diluted in TBS-T containing 3%...
Showing 1-1 of 1 papers.
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