VMA21 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC |
|---|---|
| Recommended Dilution | IHC: 150-500 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm IF: 50-200 Positive control: HepG2 and NCCIT cell Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 3-16 amino acids of human VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) |
| Database Link | |
| Background | This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase. Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. Associates with the V0 complex of the vacuolar ATPase (V-ATPase). MEAX is a childhood-onset disease characterized by progressive vacuolation and atrophy of skeletal muscle. It is inherited in recessive fashion; affecting boys and sparing carrier females. Onset is in childhood; and patients exhibit weakness of the proximal muscles of the lower extremities; progressing slowly to involve other skeletal muscle groups over time. |
| Synonyms | MEAX; XMEA |
| Reference Data | |
| Protein Categories | Membrane Proteins |
| Protein Families | Transmembrane |
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