IL18BP Rabbit Polyclonal Antibody
Anti-IL18BP Rabbit Polyclonal Antibody
Product Datasheet for 'TA323375'
|Recommend Dilution||ELISA: 1:500-5000, IHC: 1:50-200|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Fusion protein corresponding to a region derived from 31-195 of Human Interleukin-18-binding protein|
|Formulation||PBS pH7.3, 0.05% NaN3, 50% glycerol|
|Purification||Antigen affinity purification|
|Gene Name||interleukin 18 binding protein|
|Background||The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine; IL18. It binds IL18; prevents the binding of IL18 to its receptor; and thus inhibits IL18-induced IFN-gamma production; resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.|
|Protein Families||Secreted Protein, Druggable Genome|
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