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LILRB3 Rabbit Polyclonal Antibody

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SKU
TA323298
Anti-LILRB3 Rabbit Polyclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $305.00
In Stock*
Bulk/Customize

Frequently Bought Together (2)

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LY416371 Transient overexpression lysate of leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (LILRB3), transcript variant 2 (as WB positive control) 100 ug
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View other "LILRB3 or NM_006864" antibodies

Specifications
Specifications
Product Data
Application IHC
Recommended Dilution IHC: 15-50
Positive control: Human breast cancer
Predicted cell location: Cytoplasm, Cell membrane
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide peptide corresponding to a region derived from 560-572 amino acids of human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Buffer PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name leukocyte immunoglobulin like receptor B3
Database Link
Background This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family; which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains; a transmembrane domain; and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3; LIR3; PIRB
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway
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Documents
Resources

file-alt Citations

17β-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B
Wang, Wu
Mol Med Rep (2016)
Cited by 3
AI Summary: OriGene's Rabbit anti-PirB antibody (ta323298) was used in this study to detect PirB protein levels, helping to demonstrate that 17β-estradiol reduces PirB expression and protects oligodendrocyte precursor cells from hyperoxia-induced apoptosis.
Snippet: non-fat dry milk in Tris-buffered saline (TBS), containing 0.01% Tween-20 (TBS-T) for 1 h at 37˚C. The membranes were subsequently incubated with the following primary monoclonal antibodies overnight at 4˚C: Rabbit anti-PriB (1:1,000;ta323298;OriGene ... Cite SaveSaving
WB
Showing 1-1 of 1 papers.
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