ABHD12 Rabbit Polyclonal Antibody

SKU TA323295

Anti-ABHD12 Rabbit Polyclonal Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 25-100; Positive control: Human thyroid cancer; Predicted cell location: Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 96-398 amino acids of human abhydrolase domain containing 12
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: abhydrolase domain containing 12
• Database Link:
  NP_056415
  Q8N2K0
• Background: This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG); the main endocannabinoid lipid transmitter that acts on cannabinoid receptors; CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes; including neurotransmission; mood; appetite; pain appreciation; addiction behavior; and inflammation. Mutations in this gene are associated with the neurodegenerative disease; PHARC (polyneuropathy; hearing loss; ataxia; retinitis pigmentosa; and cataract); resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
• Synonyms: ABHD12A; BEM46L2; C20orf22; dJ965G21.2; PHARC

Reference Data

• Protein Families: Protease, Transmembrane