HCN2 Rabbit Polyclonal Antibody

CAT#: TA323205

Anti-HCN2 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA323205 (HCN2 Antibody) at dilution 1/80 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA323205 (HCN2 Antibody) at dilution 1/80, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA323205 (HCN2 Antibody) at dilution 1/80 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA323205 (HCN2 Antibody) at dilution 1/80, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 874-886 amino acids of Human hyperpolarization activated cyclic nucleotide-gated potassium channel 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hyperpolarization activated cyclic nucleotide gated potassium channel 2
• Database Link:
  NP_001185
  Entrez Gene 15166 MouseEntrez Gene 114244 RatEntrez Gene 610 Human
  UniProt ID Q9UL51
• Background: Hyperpolarization-activated cation channels of the HCN gene family; such as HCN2; contribute to spontaneous rhythmic activity in both heart and brain. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
• Synonyms: BCNG-2; BCNG2; HAC-1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Cyclic nucleotide gated, Transmembrane