CDK9 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: 823 and Hela cells |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 19-315 amino acids of human cyclin-dependent kinase 9 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 53 kDa |
| Gene Name | cyclin-dependent kinase 9 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28; and S. pombe cdc2; and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb; which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T; which suggested a possible involvement of this protein in AIDS. |
| Synonyms | C-2k; CDC2L4; CTK1; PITALRE; TAK |
| Reference Data | |
| Protein Categories | Cytokines, Enzyme: Kinases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase, Transcription Factors |
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